Nucleotide sequence analysis of the HA1 coding portion of the haemagglutinin gene of swine H1N1 influenza viruses
Identifieur interne : 001F38 ( Main/Exploration ); précédent : 001F37; suivant : 001F39Nucleotide sequence analysis of the HA1 coding portion of the haemagglutinin gene of swine H1N1 influenza viruses
Auteurs : Elisabeth Neumeier [Allemagne] ; Herbert Meier-Ewert [Allemagne]Source :
- Virus Research [ 0168-1702 ] ; 1992.
English descriptors
- Teeft :
- Acta virol, Amino, Amino acid changes, Amino acid residues, Amino acid sequence data, Amino acid sequences, Amino acid substitutions, Amino acid tree, Amino acids, Antigenic, Antigenic sites, Antigenic variation, Branch lengths, Classic swine influenza, Classic swine influenza virus, Coding portion, European swine influenza strains, Globular head region, Glycosylation, Glycosylation site, Glycosylation sites, Haemagglutinin, Haemagglutinin gene, Hlnl, Hlnl influenza virus, Hlnl influenza viruses, Hlnl subtype, Human hlnl influenza viruses, Human hlnl strains, Human influenza, Human influenza virus, Human strains, Influenza, Influenza strain, Influenza virus, Influenza viruses, Neutralizing antibodies, Nucleic acids, Nucleotide, Nucleotide sequence, Nucleotide sequences, Nucleotide tree, Other sequences, Phylogenetic, Phylogenetic analysis, Phylogenetic tree, Phylogenetic trees, Potential glycosylation site, Sequence data, Sequence differences, Sequence distance matrix, Sequence homologies, Serological evidence, Strain abbreviations, Swine, Swine influenza, Swine influenza virus, Swine influenza viruses, Version felsenstein, Virus.
Abstract
Abstract: The nucleotide and deduced amino acid sequences coding for the HA1 portion of the haemagglutinin (HA) genes of three swine influenza viruses were determined and compared with published HA sequence data for human H1N1 influenza viruses. Sequence differences between the classic swine influenza HAs sw37 (A/swine/29/37) and NJ76 (A/New Jersey/11/76) were randomly distributed in the molecule without being confined to antigenic sites. In contrast, sequence differences between the HAs of sw37 and the antigenically atypical strains sw38 (A/swine/Northern Ireland/38) and sw39 (A/swine/Cambridge/39) were clustered in hypervariable regions, similar to the pattern of changes that was present between sw37 and the human strains PR834 (A/PR/8/34) and WSN33 (A/WSN/33). Sequence homologies of the European swine influenza strains (sw38, sw39) were higher with the HAs of the human strains (PR834, WSN33) than with the classic swine influenza HAs (sw37, NJ76). Phylogenetic analysis showed that the HA genes of these two European swine influenza strains emerged from a different evolutionary lineage of H1 HAs than the HAs of classic swine influenza strains.
Url:
DOI: 10.1016/0168-1702(92)90071-G
Affiliations:
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tree</term><term>Phylogenetic trees</term><term>Potential glycosylation site</term><term>Sequence data</term><term>Sequence differences</term><term>Sequence distance matrix</term><term>Sequence homologies</term><term>Serological evidence</term><term>Strain abbreviations</term><term>Swine</term><term>Swine influenza</term><term>Swine influenza virus</term><term>Swine influenza viruses</term><term>Version felsenstein</term><term>Virus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The nucleotide and deduced amino acid sequences coding for the HA1 portion of the haemagglutinin (HA) genes of three swine influenza viruses were determined and compared with published HA sequence data for human H1N1 influenza viruses. Sequence differences between the classic swine influenza HAs sw37 (A/swine/29/37) and NJ76 (A/New Jersey/11/76) were randomly distributed in the molecule without being confined to antigenic sites. In contrast, sequence differences between the HAs of sw37 and the antigenically atypical strains sw38 (A/swine/Northern Ireland/38) and sw39 (A/swine/Cambridge/39) were clustered in hypervariable regions, similar to the pattern of changes that was present between sw37 and the human strains PR834 (A/PR/8/34) and WSN33 (A/WSN/33). Sequence homologies of the European swine influenza strains (sw38, sw39) were higher with the HAs of the human strains (PR834, WSN33) than with the classic swine influenza HAs (sw37, NJ76). Phylogenetic analysis showed that the HA genes of these two European swine influenza strains emerged from a different evolutionary lineage of H1 HAs than the HAs of classic swine influenza strains.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li></region><settlement><li>Munich</li></settlement><orgName><li>Université technique de Munich</li></orgName></list><tree><country name="Allemagne"><region name="Bavière"><name sortKey="Neumeier, Elisabeth" sort="Neumeier, Elisabeth" uniqKey="Neumeier E" first="Elisabeth" last="Neumeier">Elisabeth Neumeier</name></region><name sortKey="Meier Ewert, Herbert" sort="Meier Ewert, Herbert" uniqKey="Meier Ewert H" first="Herbert" last="Meier-Ewert">Herbert Meier-Ewert</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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